منابع مشابه
The role of tunable activation thresholds in the dynamics of autoimmunity.
It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes, processed from viral proteins, mimic normal host...
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The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although molecular mechanisms explaining the development of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknown, we recently demonstrated that SSc patients overexpress CD19, an important regulatory molecule ...
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(See e.g. [2], [6] or [18]. Of course p0(n) is not quite unique, but following common practice we will often say “the” threshold when we should really say “a.”) It follows from [8] that every {Fn} has a threshold, and that in fact (see e.g. [18, Proposition 1.23 and Theorem 1.24]) p0(n) := pc(Fn) is a threshold for {Fn}. So the quantity pc conveniently captures threshold behavior, in particular...
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Abstract Extended Oligopoly models will be introduced and examined in which the firms might face capacity limits, thresholds for minimal and maximal moves, and antitrust thresholds in the case of partial cooperation. Similar situation occurs when there is an additional cost of output adjustment, which is discontinuous at zero due to set-up costs. In these cases the payoff functions of the...
متن کامل[Autoimmunity].
Autoimmune diseases comprise a large, diverse group of diseases characterized by a humoral or cell-mediated immune response against the constituents of the body's own tissues. In cases in which the host is sensitized with a tissue-specific antigen, a single pathological immune reaction occurs in the target organ. In those cases in which the host is sensitized with either a single tissue nonspec...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2012
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2461